Поставщики с проверенными бизнес-лицензиями
Сертифицированный Поставщик
| Product Name | PNC-27 |
| Appearance | White Powder |
| Purity | 99.0%min. HPLC |
| Application | Drug peptides |
| Shelf Life | 24Months |
| Storage | Refrigeration keep dry and away from light. |
Description
The anticancer peptide PNC-27, which contains an HDM-2-binding domain corresponding to residues 12-26 of
p53 and a transmembrane-penetrating domain, has been found to kill cancer cells (but not normal cells) by
inducing membranolysis. We find that our previously determined 3D structure of the p53 residues of PNC-27 is
directly superimposable on the structure for the same residues bound to HDM-2, suggesting that the peptide may
target HDM-2 in the membranes of cancer cells.
Application&Function
We now find significant levels of HDM-2 in the membranes of a varietyof cancer cells but not in the membranes of
several untransformed cell lines. In colocalization experiments, we find that PNC-27 binds to cell membrane-bound
HDM-2. We further transfected a plasmid expressing full-length HDM-2 with a membrane-localization signal into
untransformed MCF-10-2A cells not susceptible to PNC-27 and found that these cells expressing full-length HDM-2
on their cell surface became susceptible to PNC-27. We conclude that PNC-27 targets HDM-2 in the membranes of
cancer cells, allowing it to induce membranolysis of these cells selectively.
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| 45051511 | Semaglutide 5mg |
| 45051512 | Semaglutide 10mg |
| 45051513 | Semaglutide+Vitamin B12 |
| 45051514 | Semaglutide+Vitamin B6 |
| 45051515 | Semaglutide+L-Carnitine |
| 45051516 | Semaglutide cartridges 5mg |
| 45051517 | Semaglutide cartridges 10mg |
| 45051518 | Setmelanotide 20mg |
| 45051519 | Tirzepatide 5mg |
| 45051520 | Tirzepatide 10mg |
| 45051521 | Tirzepatide 15mg |
| 45051522 | Tirzepatide 20mg |
| 45051523 | Tirzepatide 30mg |
| 45051524 | Tirzepatide+Vitamin B12 |
| 45051525 | Liraglutide 10g |
| 45051526 | Retatrutide 8mg |
| 45051527 | Retatrutide 10mg |
| 45051528 | Retatrutide 12mg |
| 45051529 | Orforglipron 1g |
| 45051530 | Mazdutide 1g |
| 45051531 | NAD+ 500mg |
| 45051532 | NAD+ 750mg |
| 45051533 | NAD+ 1000mg |
| 45051534 | NMN 150mg |
| 45051538 | Adipotide/FTPP 10mg |
| 45051539 | α-Klotho (Alpha Klotho) 50µg |
| 45051541 | A960 5mg |
| 45051542 | ARA-290 16mg |
| 45051543 | 57 5mg |
| 45051544 | 57 10mg |
| 45051545 | B7-33 5mg |
| 45051546 | cAC-253 (Cyclic AC-253) 10mg |
| 45051549 | DSIP 5mg |
| 45051550 | DSIP 10mg |
| 45051551 | Epitalon 10mg |
| 45051552 | Epitalon 20mg |
| 45051553 | Epitalon 100mg |
| 45051554 | FG loop (FGL) 10mg |
| 45051556 | F344 1mg |
| 45051557 | FOXO4-DRI 10mg |
| 45051559 | GHK-Cu (Copper Peptide) 50mg |
| 45051560 | GHK-Cu (Copper Peptide) 100mg |
| 45051561 | G2 10mg |
| 45051562 | G6 10mg |
| 45051563 | Gona 10mg |
| 45051564 | HC5000 |
| 45051565 | Hexa 2mg |
| 45051566 | Hexa 5mg |
| 45051568 | Humanin 10mg |
| 45051573 | Ipam 5mg |
| 45051575 | Kisspeptin-10 5mg |
| 45051576 | Kisspeptin-10 10mg |
| 45051577 | KPV 5mg |
| 45051578 | KPV 10mg |
| 45051579 | LL-37 (CAP-18) 5mg |
| 45051580 | Melanotan 1 10mg |
| 45051581 | Melanotan 2 10mg |
| 45051582 | MOTS-c 5mg (acetate, TFA removed) |
| 45051583 | MOTS-c 10mg (acetate, TFA removed) |
| 45051584 | N-Acetyl Epitalon Amidate 10mg |
| 45051585 | N-Acetyl Selank Amidate 10mg |
| 45051586 | N-Acetyl Semax Amidate 30mg |
| 45051587 | Oxytocin 10mg |
| 45051588 | PNC-27 5mg |
| 45051590 | P21 (P021) 5mg |
| 45051591 | Selank 10mg |
| 45051592 | Semax 10mg |
| 45051593 | Sermo 2mg |
| 45051594 | Sermo 5mg |
| 45051595 | SS-31 40mg |
| 45051596 | Taltirelin 10mg |
| 45051597 | Tesam 2mg |
| 45051598 | Tesam 5mg |
| 45051600 | Thymalin 20mg (63958-90-7) |
| 45051601 | Thymosin Alpha-1 3mg |
| 45051602 | Thymosin Alpha-1 5mg |
| 45051603 | Thymosin Alpha-1 10mg |
| 45051604 | Thymosinb4 5mg |
| 45051605 | Thymosinb4 10mg |
| 45051607 | TP508 Thrombin Peptide 10mg |
| 45051608 | TRH Thyrotropin (Protirelin Acetate) 20mg |
| 45051609 | VIP (Vasoactive Intestinal Peptide) 6mg |
| 45051610 | Bronchogen (Bronchi) 20mg |
| 45051611 | Cardiogen (Myocardium) 20mg |
| 45051612 | Cartalax (Joints) 20mg |
| 45051613 | Chonluten (Respiratory organs) 20mg |
| 45051614 | Cortagen (Brain) 20mg |
| 45051615 | Crystagen (Immune system) 20mg |
| 45051616 | Livagen (Liver) 20mg |
| 45051617 | Pancragen (Pancreas) 20mg |
| 45051618 | Pinealon (Brain) 20mg |
| 45051619 | Prostamax (Prostate) 20mg |
| 45051620 | Testagen (Testes) 20mg |
| 45051621 | Vesugen (Blood vessels) 20mg |
| 45051622 | Vilon (Eye retina) 20mg |
| 45051623 | B15, T50 Blend 10mg |
Our Advantages: High purity, Wholesale price, large stock, Stealth Shipping, 100% Delivery Guarantee
Our advantages:
Goods quality
Upstream peptide synthesis
Zhaobo Bio production plants are endowed with state-of-the-art equipment for solvent supply, peptide synthesis, purification and isolation of active ingredients and intermediates. All equipment and containment is GMP qualified and cleaning validated. Overlapping capacities and sizes of different equipment trains facilitate a smooth scale-up for increases in demand within the product life cycle.
Downstream purification and isolation of peptides
Zhaobo Bio is committed to the systematic expansion and modernization of its purification equipment in order to ensure the efficient production of ever-increasing amounts of bulk peptide pharmaceuticals.
It uses sophisticated methods for large scale purification campaigns such as preparative high performance liquid chromatography (HPLC), ion exchange (IEX), size-exclusion chromatography (SEC), and ultra-filtration (UF/TFF). The equipment in place permits highly efficient or even continuous manufacturing of extremely pure products up to multi-kg quantities per lot.
For preparative HPLC, dynamic axial compression (DAC) stainless steel columns of up to 60 cm diameter both in batch and continuous mode are packed with the appropriate high performance silica separation phase. For low-pressure chromatography columns up to 80 cm diameter are available. Solvent delivery is ensured from eluent tank farms and containers.
The control of microbiological contamination is a prerequisite for API manufacturing. Class D (ISO 8) and C (ISO 7) clean rooms are supplied via HEPA-filtered, temperature and humidity controlled air, down-flow booths are used for minimizing microbial contamination and protecting operators. Highly active pharmaceutical ingredients are handled in integrated safety workbenches or flexible isolators reaching OEB level 4 (1-10 µg/m3).
Predefined physicochemical properties of the API can only be achieved by a carefully controlled isolation process. Besides precipitation and crystallization, lyophilization of intermediates and final API is a standard unit operation. LaixingPharma have multiple lyophilizers in different sizes (up to 300 liters) located in clean room
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Поставщики с проверенными бизнес-лицензиями
Сертифицированный Поставщик 
